The most striking characteristic of CHO cells is their adaptability, which enables efficient
production of proteins as well as growth under a variety of culture conditions, but also results …

Many organisms monitor the annual change in day length and use this information for the
timing of their seasonal response. However, the molecular mechanisms underlying …

In MS‐based quantitative proteomics, the FDR control (ie the limitation of the number of
proteins that are wrongly claimed as differentially abundant between several conditions) is a …

DNA methylation is an epigenetic modification involved in organism development and
cellular differentiation. Identifying differential methylations can help to study genomic regions …

We hypothesised that epigenetic regulation of CD4+ T lymphocytes contributes to a shift
toward a dysfunctional T cell phenotype which may impact on their ability to clear …

The sex drive hypothesis predicts that stronger selection on male traits has resulted in
masculinization of the genome. Here we test whether such masculinizing effects can be …

Traditional testis histopathology endpoints remain the gold standard for evaluating testicular
insult and injury in a non-clinical setting, but are invasive and unfeasible for monitoring …

We are presenting a comprehensive comparative analysis of five differential methylation
(DM) identification methods: methylKit, BSmooth, BiSeq, HMM-DM, and HMM-Fisher, which …

Epigenetic changes, like DNA methylation, affect gene expression and in colorectal cancer
(CRC), a distinct phenotype called the CpG island methylator phenotype (“CIMP”) has …

Vascular smooth muscle cell (VSMC) accumulation in the neointimal is a common feature in
vascular diseases such as atherosclerosis, transplant arteriosclerosis and restenosis. In this …