Importance The rising threat of antibiotic resistance and other adverse consequences
resulting from the misuse of antibiotics requires a better understanding of antibiotic use in …

Objective Some previously developed risk scores contained a mathematical error in their
construction: risk ratios were added to derive weights to construct a summary risk score. This …

Despite the growing number of frail and older patients with eGFR< 45 mL/min/1.73 m2, most
studies still exclude this population, so providing guidance on the management of these …

ABSTRACT The US Food and Drug Administration (FDA) issued several announcements
related to potential risk of bisphosphonates including osteonecrosis of the jaw (2005), atrial …

Objective: Compare diagnosis-based and prescription-based comorbidity scores for
predicting surgical outcomes. Methods: We used 100% Texas Medicare data (2006–2011) …

Background Administrative data are increasingly used in healthcare research. However, in
order to avoid biases, their use requires careful study planning. This paper describes the …

Background The use of inpatient rehabilitation services after total joint arthroplasty (TJA) is
an important driver of episode-of-care costs. We determined the utility of a new standardized …

Rationale: Little is known about the effectiveness of noninvasive ventilation for patients
hospitalized with asthma exacerbation. Objectives: To assess clinical outcomes of …

Results Two thirds (67.1%) of cohort members received RRT on the basis of administrative
data. On the basis of the results of chart review, we estimate that an additional 7.5%(95 …

Shahraz et al2 elegantly demonstrate how common conditions can be “medicalized.” Using
NHANES data they find that a widely promoted web-based risk test would label more than …