Cardiovascular disease (CVD) is one of the leading causes of death worldwide. The most
significant risk factors associated with the development of heart diseases include genetic …

We performed whole-genome sequencing (WGS) of 208 genomes from 53 families affected
by simplex autism. For the majority of these families, no copy-number variant (CNV) or …

Cleft palate (CP) is a common birth defect occurring in 1 in 2,500 live births. Approximately
half of infants with CP have a syndromic form, exhibiting other physical and cognitive …

Our current understanding of the developmental biology of the enteric nervous system (ENS)
and the genesis of ENS diseases is founded almost entirely on studies using model …

Although genome sequencing has identified numerous noncoding alterations between
primate species, which of those are regulatory and potentially relevant to the evolution of the …

Small freshwater fish models, especially zebrafish, offer advantages over traditional rodent
models, including low maintenance and husbandry costs, high fecundity, genetic diversity …

Genomic approaches have predicted hundreds of thousands of tissue-specific cis-regulatory
sequences, but the determinants critical to their function and evolutionary history are mostly …

The kidney of the zebrafish shares many features with other vertebrate kidneys including the
human kidney. Similar cell types and shared developmental and patterning mechanisms …

Patterning of C. elegans vulval cell fates relies on inductive signaling. In this induction event,
a single cell, the gonadal anchor cell, secretes LIN-3/EGF and induces three out of six …

Vertebrates, as most animal phyla, originated> 500 million years ago during the Cambrian
explosion, and progressively radiated into the extant classes. Inferring the evolutionary …