In vitro cardiac tissue models: current status and future prospects

A Mathur, Z Ma, P Loskill, S Jeeawoody… - Advanced drug delivery …, 2016 - Elsevier
Cardiovascular disease is the leading cause of death worldwide. Achieving the next phase
of potential treatment strategies and better prognostic tools will require a concerted effort …

Human pluripotent stem cells: Prospects and challenges as a source of cardiomyocytes for in vitro modeling and cell-based cardiac repair

ME Hartman, DF Dai, MA Laflamme - Advanced drug delivery reviews, 2016 - Elsevier
Human pluripotent stem cells (PSCs) represent an attractive source of cardiomyocytes with
potential applications including disease modeling, drug discovery and safety screening, and …

Tissue engineering and regenerative medicine 2015: a year in review

H Wobma, G Vunjak-Novakovic - Tissue Engineering Part B …, 2016 - liebertpub.com
This may be the most exciting time ever for the field of tissue engineering and regenerative
medicine (TERM). After decades of progress, it has matured, integrated, and diversified into …

Neural stem cells derived from human parthenogenetic stem cells engraft and promote recovery in a nonhuman primate model of Parkinson's disease

R Gonzalez, I Garitaonandia… - Cell …, 2016 - journals.sagepub.com
Cell therapy has attracted considerable interest as a promising therapeutic alternative for
patients with Parkinson's disease (PD). Clinical studies have shown that grafted fetal neural …

Human embryonic stem cells

P Damdimopoulou, S Rodin, S Stenfelt… - Best Practice & …, 2016 - Elsevier
Highlights•Human embryonic stem cell (hESC) can be derived from a single eight-cell
embryo blastomere.•hESC can be derived, expanded, and maintained in defined, xeno-free …

[HTML][HTML] Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies

K Azuma, S Yamanaka - Regenerative Therapy, 2016 - Elsevier
In Japan, a research center network consisting of Kyoto University to provide clinical-grade
induced Pluripotent Stem Cells (iPSC) and several major research centers to develop iPSC …

New strategies for improving stem cell therapy in ischemic heart disease

P Huang, X Tian, Q Li, Y Yang - Heart failure reviews, 2016 - Springer
Stem cell therapy is a promising approach to the treatment of ischemic heart disease via
replenishing cell loss after myocardial infarction. Both preclinical studies and clinical trials …

Understanding stem cell immunogenicity in therapeutic applications

KJ Wood, F Issa, J Hester - Trends in immunology, 2016 - cell.com
Stem cells and their differentiated progeny offer great hope for treating disease by providing
an unlimited source of cells for repairing or replacing damaged tissue. Initial studies …

Developmental potential of clinically discarded human embryos and associated chromosomal analysis

G Yao, J Xu, Z Xin, W Niu, S Shi, H Jin, W Song… - Scientific reports, 2016 - nature.com
Clinically discarded human embryos, which are generated from both normal and abnormal
fertilizations, have the potential of developing into blastocysts. A total of 1,649 discarded …

Pluripotent stem cells: the last 10 years

EA Kimbrel, R Lanza - Regenerative Medicine, 2016 - Taylor & Francis
Pluripotent stem cells (PSCs) can differentiate into virtually any cell type in the body, making
them attractive for both regenerative medicine and drug discovery. Over the past 10 years …