1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

The vitamin D receptor (VDR) is found in nearly all, if not all, cells in the body. The enzyme
that produces the active metabolite of vitamin D and ligand for VDR, namely CYP27B1 …

Objective: We sought to estimate the causal effect of low serum 25 (OH) D on multiple
sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or …

Objectives: Autism spectrum disorder (ASD) is a developmental disorder characterized by
pervasive deficits in social interaction, impairment in verbal and non-verbal communication …

In many cells throughout the body, vitamin D is converted into its active form calcitriol and
binds to the vitamin D receptor (VDR), which functions as a transcription factor to regulate …

Vitamin D deficiency has been associated with a wide range of diseases and multiple forms
of cancer including breast, colon, and prostate cancers. Relatively recent work has …

Vitamin D insufficiency is a worldwide epidemic affecting billions of individuals, including
pregnant women and children. Despite its high incidence, the impact of active vitamin D3 (1 …

Background Mood disorders in pregnancy and post-partum period are common and
considered as a public health issue. Researchers have studied the relationship between low …

Background: Vitamin D exerts anti-inflammatory actions both in vitro and in murine models of
colitis. In previous studies, we demonstrated that vitamin D protects against the development …

Insight into mechanisms that link the actions of 1, 25-dihydroxyvitamin D 3 (1, 25 (OH) 2 D 3)
to the regulation of gene expression has evolved extensively since the initial discovery of a …