Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

One hundred and fifty years ago Max Schultze first proposed the duplex theory of vision, that
vertebrate eyes have two types of photoreceptor cells with differing sensitivity: rods for dim …

Cone photoreceptors (cones) are essential for high-resolution daylight vision and colour
perception. Loss of cones in hereditary retinal diseases has a dramatic impact on human …

The eye is the sensory organ of vision. There, the retina transforms photons into electrical
signals that are sent to higher brain areas to produce visual sensations. In the light path to …

Substitutions of Arg 838 in the dimerization domain of a human retinal membrane guanylyl
cyclase 1 (RetGC1) linked to autosomal dominant cone-rod degeneration type 6 (CORD6) …

This monograph presents a historical perspective of cornerstone developments on the
biochemistry and physiology of mammalian membrane guanylate cyclases (MGCs) …

Recent studies have implicated thyroid hormone (TH) signaling in cone photoreceptor
viability. Using mouse models of retinal degeneration, we found that antithyroid treatment …

Colour vision is only achieved in the presence of healthy and functional cone
photoreceptors found in the retina. It is an essential component of human vision and usually …

Cone photoreceptor cyclic nucleotide-gated (CNG) channels play a pivotal role in cone
phototransduction, which is a process essential for daylight vision, color vision, and visual …

RETINITIS PIGMENTOSA (RP) IS A DEBILITATING EYE DISEASE AFFECTING 1 IN 5000
PEOPLE. RP PATIENTS EXHIBIT ROD AND CONE PHOTORECEPTOR DEGENERATION …