Poorly differentiated thyroid carcinoma (PDTC) and anaplastic thyroid carcinoma (ATC) are
aggressive thyroid tumors associated with a high mortality rate of 38–57% and almost 100 …

BACKGROUND. Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer
(ATC) are rare and frequently lethal tumors that so far have not been subjected to …

Genetic predictors of outcome are reviewed in the context of a disease–cancer–that can be
(too) simplistically described as a 'successful, invasive clone of our own tissues'. Context has …

MicroRNAs (miRNAs) are small non-coding RNA comprising approximately 19–25
nucleotides. miRNAs can act as tumour suppressors or oncogenes, and aberrant expression …

Anaplastic thyroid carcinoma (ATC) is the most aggressive thyroid cancer with a median
survival of 4–6 months. Identification of mutations contributing to aberrant activation of …

More than half of human tumors harbor an inactivated p53 tumor-suppressor gene. It is well
accepted that mutant p53 shows an oncogenic gain-of-function (GOF) activity that facilitates …

Abstract The BRAF V600E mutation is found in approximately 40% of papillary thyroid
cancers (PTC). Mice with thyroid-specific expression of Braf V600E (TPO–Braf V600E) …

The efficacy of targeted monotherapy for BRAF V600E-positive anaplastic thyroid
carcinomas (ATC) is not established. We report 2 cases of BRAF V600E-positive ATC …

Purpose This study aimed to investigate the expression of glutamine metabolism-related
protein in tumor and stromal compartments among the histologic subtypes of thyroid cancer …

Opinion Statement Radioiodine refractory differentiated thyroid cancer (RAI-R DTC) is a
challenging malignancy with limited prognosis and treatment options. Recently, clinical trials …