Ethnic and geographic differences in cancer incidence, prognosis, and treatment outcomes
can be attributed to diversity in the inherited (germline) and somatic genome. Although …

Abstract Disparities between African American and Caucasian men in prostate cancer (PCa)
diagnosis and treatment in the United States have been well established, with significant …

Background The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate
precisely associated cancer risks. Population-based family studies have provided evidence …

The role of insulin-like growth factors (IGF) in prostate cancer development is not fully
understood. To investigate the association between circulating concentrations of IGFs (IGF-I …

We report targeted sequencing of 63 known prostate cancer risk regions in a multi-ancestry
study of 9,237 men and use the data to explore the contribution of low-frequency variation to …

Molecular characterization of genome-wide association study (GWAS) loci can uncover key
genes and biological mechanisms underpinning complex traits and diseases. Here we …

Prostate cancer (PC) has the highest degree of genetic transmission of any form of
malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal …

Abstract Background: The K3326X variant in BRCA2 (BRCA2* c. 9976A> T; p. Lys3326*;
rs11571833) has been found to be associated with small increased risks of breast cancer …

We conducted a meta-analysis of three endometrial cancer genome-wide association
studies (GWAS) and two follow-up phases totaling 7,737 endometrial cancer cases and …

Single nucleotide polymorphisms (SNPs) have been classically used for dissecting various
human complex disorders using candidate gene studies. During the last decade, large scale …