Traditionally, vaccines have been developed by cultivating infectious agents and isolating
the inactivated whole pathogen or some of its purified components. 20 years ago, reverse …

Outbreaks from zoonotic sources represent a threat to both human disease as well as the
global economy. Despite a wealth of metagenomics studies, methods to leverage these …

Influenza virus remains a threat because of its ability to evade vaccine-induced immune
responses due to antigenic drift. Here, we describe the isolation, evolution, and structure of a …

Abstract The Middle East respiratory syndrome coronavirus (MERS-CoV) is a novel zoonotic
pathogen. In 2012, the infectious outbreak caused by MERS-CoV in Saudi Arabia has …

Zika virus (ZIKV), a mosquito-borne flavivirus with homology to Dengue virus (DENV), has
become a public health emergency. By characterizing memory lymphocytes from ZIKV …

Ebola virus disease in humans is highly lethal, with case fatality rates ranging from 25 to
90%. There is no licensed treatment or vaccine against the virus, underscoring the need for …

Human cytomegalovirus encodes at least 25 membrane glycoproteins that are found in the
viral envelope 1. While gB represents the fusion protein, two glycoprotein complexes control …

Plasmodium falciparum antigens expressed on the surface of infected erythrocytes are
important targets of naturally acquired immunity against malaria, but their high number and …

Currently available rabies post‐exposure prophylaxis (PEP) for use in humans includes
equine or human rabies immunoglobulins (RIG). The replacement of RIG with an equally or …

Monoclonal antibodies are essential therapeutics and diagnostics in a large number of
diseases. Moreover, they are essential tools in all sectors of life sciences. Although the great …