The transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) is the master
regulator of the cellular redox homeostasis. Nrf2 target genes comprise of a large network of …

The identification of bioactive molecules that have potential to interrupt carcinogenesis
continues to garner research interest. In particular, molecules that have dietary origin are …

1. ABSTRACT A large body of evidence points to the positive effects of dietary
supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in …

Aging process is often accompanied with a high incidence of cardiovascular diseases (CVD)
due to the synergistic effects of age-related changes in heart morphology/function and …

Although several efforts have been made in the search for genetic and epigenetic patterns
linked to diseases, a comprehensive explanation of the mechanisms underlying …

Natural xanthones have diversity pharmacological activities. Here, a series of xanthones
isolated from the pericarps of Garcinia mangostana Linn, named α-Mangostin, 8 …

Background Animals exposed to sevoflurane during development sustain neuronal cell
death in their developing brains. In vivo micro-positron emission tomography …

In the United States, 1.1–1.5% of children have been diagnosed with autism spectrum
disorders (ASD), corresponding to a 30% increase in incidence and prevalence. Social and …

Guanosine, a guanine-based purine, has been shown to exert beneficial roles in in vitro and
in vivo injury models of neural cells. Guanosine is released from astrocytes and modulates …

A growing body of evidence has focused on the impact of mitochondrial disturbances in the
development of depression, but little data exist regarding the effects of chronic …