Recent technological advances have made it possible to decode DNA methylomes at single-
base-pair resolution under various physiological conditions. Many aberrant or differentially …

Chromatin is a highly dynamic structure that imparts structural organization to the genome
and regulates the gene expression underneath. The decade long research in deciphering …

Cell fate specification relies on the action of critical transcription factors that become
available at distinct stages of embryonic development. One such factor is NeuroD1, which is …

Abstract Histone deacetylases (HDACs) 1, 2 and 3 form the catalytic subunit of several large
transcriptional repression complexes. Unexpectedly, the enzymatic activity of HDACs in …

The NuRD complex is a multi-protein transcriptional corepressor that couples histone
deacetylase and ATP-dependent chromatin remodelling activities. The complex regulates …

In 1964, Alfrey and colleagues proposed that acetylation and methylation of histones may
regulate RNA synthesis and described “the possibility that relatively minor modifications of …

DNA methylation is an epigenetic mark that is essential for many biological processes and is
linked to diseases such as cancer. Methylation is usually associated with transcriptional …

Epigenetic silencing and inappropriate activation of gene expression are frequent events
during the initiation and progression of cancer. These events involve a complex interplay …

Disruption of the intricate gene expression program represents one of major driving factors
for the development, progression and maintenance of human cancer, and is often …

Methylation of histone H3 lysine 4 is linked to active transcription and can be removed by
LSD 1 or the JmjC domain‐containing proteins by amino‐oxidation or hydroxylation …