Importance Although multiple HLA alleles associated with multiple sclerosis (MS) risk have
been identified, genotype-phenotype studies in the HLA region remain scarce and …

Multiple Sclerosis (MS) is an autoimmune degenerative disease of the central nervous
system, characterized by multifocal demyelination and neurodegeneration. The genetic …

Background The genetic drivers of multiple sclerosis (MS) clinical course are essentially
unknown with limited data arising from severity and clinical phenotype analyses in genome …

Objective: To compare vitamin D level–associated single-nucleotide polymorphisms (SNPs)
in GC and CYP2R1, multiple sclerosis (MS) risk SNPs in CYP27B1, CYP24A1, and HLA …

Objective: To examine the relationship between 2 markers of early multiple sclerosis (MS)
onset, 1 genetic (HLA-DRB1* 1501) and 1 experiential (early menarche), in 2 cohorts …

Abstract Background The HLA-DRB* 1501 haplotype influences the risk of developing
multiple sclerosis (MS), but it is not known how it affects grey matter pathology. Aim To …

To the Editor Isobe and colleagues1 studied the association of HLA genetic burden with
mainly magnetic resonance imaging (MRI)–based disease phenotypes in a large cohort of …

Цель исследования. Рассеянный склероз (РС) имеет мультифакторную природу. Для
исследований роли генетической составляющей в патогенезе заболевания …

Изучение факторов, влияющих на риск развития врожденных пороков сердца (ВПС),
является актуальным для современной медицины. Поиску предикторов, которые …

Sclerosismultiplex (multiplesclerosis, MS) isachronicautoimmuneinflammatory disease of
the central nervous system. The immune regulatory defects lead to the process of …