C-type lectin receptors in the control of T helper cell differentiation
TBH Geijtenbeek, SI Gringhuis - Nature Reviews Immunology, 2016 - nature.com
Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is
important not only for antigen presentation, but also for the induction of appropriate adaptive …
important not only for antigen presentation, but also for the induction of appropriate adaptive …
Targeting dendritic cells: a promising strategy to improve vaccine effectiveness
C Macri, C Dumont, APR Johnston… - Clinical & translational …, 2016 - Wiley Online Library
Dendritic cell (DC) targeting is a novel strategy to enhance vaccination efficacy. This
approach is based on the in situ delivery of antigen via antibodies that are specific for …
approach is based on the in situ delivery of antigen via antibodies that are specific for …
Expansion and activation of CD103+ dendritic cell progenitors at the tumor site enhances tumor responses to therapeutic PD-L1 and BRAF inhibition
H Salmon, J Idoyaga, A Rahman, M Leboeuf… - Immunity, 2016 - cell.com
Large numbers of melanoma lesions develop resistance to targeted inhibition of mutant
BRAF or fail to respond to checkpoint blockade. We explored whether modulation of …
BRAF or fail to respond to checkpoint blockade. We explored whether modulation of …
Cancer immunotherapy with immunomodulatory anti-CD137 and anti–PD-1 monoclonal antibodies requires BATF3-dependent dendritic cells
Weak and ineffective antitumor cytotoxic T lymphocyte (CTL) responses can be rescued by
immunomodulatory mAbs targeting PD-1 or CD137. Using Batf3−/− mice, which are …
immunomodulatory mAbs targeting PD-1 or CD137. Using Batf3−/− mice, which are …
Effective clinical responses in metastatic melanoma patients after vaccination with primary myeloid dendritic cells
Purpose: Thus far, dendritic cell (DC)-based immunotherapy of cancer was primarily based
on in vitro–generated monocyte-derived DCs, which require extensive in vitro manipulation …
on in vitro–generated monocyte-derived DCs, which require extensive in vitro manipulation …
Adjuvants for peptide-based cancer vaccines
H Khong, WW Overwijk - Journal for immunotherapy of Cancer, 2016 - Springer
Cancer therapies based on T cells have shown impressive clinical benefit. In particular,
immune checkpoint blockade therapies with anti-CTLA-4 and anti-PD-1/PD-L1 are causing …
immune checkpoint blockade therapies with anti-CTLA-4 and anti-PD-1/PD-L1 are causing …
Optimal generation of tissue-resident but not circulating memory T cells during viral infection requires crosspriming by DNGR-1+ dendritic cells
Despite the crucial role of tissue-resident memory T (Trm) cells in protective immunity, their
priming remains poorly understood. Here, we have shown differential priming requirements …
priming remains poorly understood. Here, we have shown differential priming requirements …
Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment
GF Heidkamp, J Sander, CHK Lehmann, L Heger… - Science …, 2016 - science.org
In mice, conventional and plasmacytoid dendritic cells (DCs) derive from separate
hematopoietic precursors before they migrate to peripheral tissues. Moreover, two classes of …
hematopoietic precursors before they migrate to peripheral tissues. Moreover, two classes of …
Human dendritic cells (DCs) are derived from distinct circulating precursors that are precommitted to become CD1c+ or CD141+ DCs
In humans, conventional dendritic cells (cDCs) exist as two unique populations
characterized by expression of CD1c and CD141. cDCs arise from increasingly restricted …
characterized by expression of CD1c and CD141. cDCs arise from increasingly restricted …
Characterization and transcriptomic analysis of porcine blood conventional and plasmacytoid dendritic cells reveals striking species-specific differences
G Auray, I Keller, S Python, M Gerber… - The Journal of …, 2016 - journals.aai.org
Porcine dendritic cells (DCs) are relatively well characterized, but a clear-cut identification of
all DC subsets combined with full transcriptional profiling was lacking, preventing an …
all DC subsets combined with full transcriptional profiling was lacking, preventing an …