Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …

Hypoxic tumor microenvironment (HTM) is considered to promote metabolic changes,
oncogene activation and epithelial mesenchymal transition, and resistance to chemo-and …

Altered metabolism in tumor cells has been a focus of cancer research for as long as a
century but has remained controversial and vague due to an inhomogeneous overall …

Carcinoma associated fibroblasts (CAFs) produce a nutrient-rich microenvironment to fuel
tumor progression and metastasis. Reactive oxygen species (ROS) levels and the …

HIV-1 infection leads to a depletion of CD4 T-cells associated with a persistent immune
inflammation and changes in cellular metabolism. Most effort of managing HIV infection with …

Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of
tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic …

Objectives/Hypothesis In many cancers, varying regions within the tumor are often
phenotypically heterogeneous, including their metabolic phenotype. Further, tumor regions …

Metabolic adaptations are emerging as common traits of cancer cells and tumor
progression. In vitro transformation of NIH 3T3 cells allows the analysis of the metabolic …

Tumor necrosis factor (TNF)-related apoptosis‑inducing ligand (TRAIL) is expressed in
ovarian tissue and is widely thought to exhibit strong antitumor activity in a variety of tumor …

肿瘤微环境(TME) 在局部耐药性, 免疫逃脱和远端转移等多个肿瘤发生, 发展的步骤中起关键
作用. 依据不同个体的TME, 准确评估和选择临床用药, 可有效控制原位癌和转移癌的恶性转化 …