Introduction There are several published clinical trials of the use of tranexamic acid (TXA) in
an obstetric setting, but no consensus on its use or guidelines for management. Material and …

Background Severe trauma continues to represent a global public health issue and mortality
and morbidity in trauma patients remains substantial. A number of initiatives have aimed to …

Study Design Combination of narrative and systematic literature reviews. Objectives
Massive perioperative blood loss in complex spinal surgery often requires blood …

Background Fibrinolysis is a physiologic process that maintains microvascular patency by
breaking down excessive fibrin clot. Hyperfibrinolysis is associated with a doubling of …

Revised, updated, and enhanced from cover to cover, the Sixth Edition of Greenfield's
Surgery: Scientific Principles and Practice remains the gold standard text in the field of …

BACKGROUND Massive transfusion practices have undergone several recent
developments. We sought to examine institutional practices guiding hemostatic resuscitation …

The use of tranexamic acid (TXA) as an antifibrinolytic agent was initially approved by the
Food and Drug Administration to reduce bleeding in hemophiliacs undergoing tooth …

Background Hysterectomy is one of the most frequently performed major gynecological
surgical procedures. Even when the indication for the procedure is benign, relatively high …

Gastrointestinal bleeding (GIB) is a serious, potentially life-threatening disease that leads to
almost 1 million hospitalizations annually in the United States. 1, 2 Because this is a …

Background: There is growing interest in viscoelastic hemostatic assays rotational
thromboelastometry (ROTEM) and thromboelastography (TEG) for trauma. Despite shared …