Mushroom dendritic spine structures are essential for memory storage and the loss of
mushroom spines may explain memory defects in aging and Alzheimer9s disease (AD). The …

Pathological remodelling of astroglia represents an important component of the
pathogenesis of Alzheimer's disease (AD). In AD astrocytes undergo both atrophy and …

Alzheimer's disease (AD) is an age-associated neurodegenerative brain disorder with
progressive cognitive decline that leads to terminal dementia and death. For decades …

We previously developed orthosteric M1 muscarinic agonists (eg AF102B, AF267B and
AF292), which act as cognitive enhancers and potential disease modifiers. We now report …

Presenilin 1 (PS1) is an essential γ-secretase component, the enzyme responsible for
amyloid precursor protein (APP) intramembraneous cleavage. Mutations in PS1 lead to …

Apathy is an early and common neuropsychiatric syndrome in Alzheimer's disease (AD)
patients. In clinical trials, apathy is associated with decreased motor activity that can be …

Alzheimer's disease (AD) is the most common type of dementia among the elderly.
Neurofibrillary tangles (NFTs), a major pathological hallmark of AD, are composed of tau …

Abstract Mutants of presenilin 1 (PS1) increase neuronal cell death causing autosomal-
dominant familial Alzheimer's disease (FAD). Recent literature shows that treatment of …

Excessive amount of l-glutamate in the brain causes neuronal damage in various
pathological conditions including epilepsy and stroke. We previously reported that the 150 …

This study is about the place of French and French speakers in the Saskatchewan political
community. Beginning with the political foundations of western Canada in 1870, it argues …