IFN regulatory factors and antiviral innate immunity: how viruses can get better

G Marsili, E Perrotti, AL Remoli, C Acchioni… - Journal of Interferon & …, 2016 - liebertpub.com
The interferon regulatory factor (IRF) family consists of transcriptional regulators that exert
multifaceted and versatile functions in multiple biological processes. Their crucial role as …

A viral kinase mimics S6 kinase to enhance cell proliferation

AP Bhatt, JP Wong, MS Weinberg… - Proceedings of the …, 2016 - National Acad Sciences
Viruses depend upon the host cell for manufacturing components of progeny virions. To
mitigate the inextricable dependence on host cell protein synthesis, viruses can modulate …

Discovery of a coregulatory interaction between Kaposi's sarcoma-associated herpesvirus ORF45 and the viral protein kinase ORF36

D Avey, S Tepper, B Pifer, A Bahga, H Williams… - Journal of …, 2016 - Am Soc Microbiol
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of three human
malignancies. KSHV ORF36 encodes a serine/threonine viral protein kinase, which is …

Type I interferons direct gammaherpesvirus host colonization

CSE Tan, C Lawler, JS May, GT Belz… - PLoS …, 2016 - journals.plos.org
Gamma-herpesviruses colonise lymphocytes. Murid Herpesvirus-4 (MuHV-4) infects B cells
via epithelial to myeloid to lymphoid transfer. This indirect route entails exposure to host …

Type I interferons and NK cells restrict gammaherpesvirus lymph node infection

C Lawler, CSE Tan, JP Simas, PG Stevenson - Journal of Virology, 2016 - Am Soc Microbiol
Gammaherpesviruses establish persistent, systemic infections and cause cancers. Murid
herpesvirus 4 (MuHV-4) provides a unique window into the early events of host colonization …

Modulation of kinase signaling by ORF45 during the lytic cycle of Kaposi's Sarcoma-Associated Herpesvirus

DR Avey - 2016 - search.proquest.com
Abstract Kaposi's Sarcoma-Associated Herpesvirus (KSHV) is an oncogenic virus that has
adapted unique mechanisms to modulate the cellular microenvironment of its human host …

Modulation of signal transduction and transformation by Kaposi's sarcoma-associated herpesvirus

PM Anders - 2016 - search.proquest.com
Kaposi's sarcoma associated-herpesvirus (KSHV) is a double-strand DNA gamma
herpesvirus that establishes lifelong latent infection in the human host. KSHV infection is …