Synovial proliferation, neovascularization and leukocyte extravasation transform the
normally acellular synovium into an invasive tumour-like'pannus'. The highly dysregulated …

Autophagy, an endogenous process necessary for the turnover of organelles, maintains
cellular homeostasis and directs cell fate. Alterations to the regulation of autophagy …

Background & Aims CXC chemokine receptor 3 (CXCR3) is involved in virus-related chronic
liver inflammation. However, the role of CXCR3 in non-alcoholic steatohepatitis (NASH) …

Aims/hypothesis Intra-retinal extravasation and modification of LDL have been implicated in
diabetic retinopathy: autophagy may mediate these effects. Methods Immunohistochemistry …

Objectives Autophagy has recently been shown to regulate osteoclast activity and osteoclast
differentiation. Here, we aim to investigate the impact of autophagy inhibition as a potential …

Rheumatoid arthritis affects nearly 1% of the world's population and is a debilitating
autoimmune condition that can result in joint destruction. During the past decade …

Objectives. Autophagy may represent a functional processing event that creates a substrate
for autoreactivity. In particular, autophagy may play a role in the pathogenesis of RA, since …

Objective. The present study aimed to determine the protective effects of dietary
supplementation with resveratrol (RSV) in an acute antigen-induced arthritis (AIA) model …

Abstract Intracellular calcium (Ca 2+) levels play a vital role in regulating cellular fate. The
coordination and interrelation among the cellular organelles, mainly the intracellular Ca 2+ …

Autophagy appears to play a dual role in eukaryotic cells. It manifests cytoprotective effects
through the regulation of catabolic processes and the clearance of pathogens; however, a …