Recent genomic studies have resulted in an emerging understanding of the role of
chromatin regulators in the development of cancer. EZH2, a histone methyl transferase …

Background Adenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this
study, recent advances in molecular characterization and in therapeutics are reviewed …

Mutational hotspots indicate selective pressure across a population of tumor samples, but
their prevalence within and across cancer types is incompletely characterized. An approach …

Adenoid cystic carcinoma (ACC), the second most common malignancy of salivary glands, is
a rare tumor with a bleak prognosis for which therapeutic targets are unavailable. We used …

Translocation events are frequent in cancer and may create chimeric fusions or'regulatory
rearrangements' that drive oncogene overexpression. Here we identify super-enhancer …

Purpose: Adenoid cystic carcinoma (ACC) is an indolent salivary gland malignancy,
characterized by t (6; 9) translocations and MYB–NFIB gene fusions in approximately 50% of …

Triple-negative breast cancers (TNBCs), defined by lack of expression of estrogen receptor,
progesterone receptor and HER2, account for 12–17% of breast cancers and are clinically …

Purpose: Salivary duct carcinoma (SDC) is an aggressive salivary malignancy, which is
resistant to chemotherapy and has high mortality rates. We investigated the molecular …

During development, precise spatiotemporal patterns of gene expression are coordinately
controlled by cis-regulatory modules known as enhancers. Their crucial role in development …

Uterine adenosarcomas (UAs) are biphasic lesions composed of a malignant mesenchymal
(ie stromal) component and an epithelial component. UAs are generally low‐grade and …