Ureases are metalloenzymes that hydrolyze urea into ammonia and carbon dioxide. They
were the first enzymes to be crystallized and, with them, the notion that enzymes are proteins …

Half a century after the introduction of Amphotericin B the management of cryptococcosis
remains unsatisfactory. The disease, caused primarily by the two fungal species …

Extracellular vesicles (EVs) are produced by virtually all cell types. Within the past few years,
work in this field has revealed more information about fungal EVs. Fungal EVs have been …

Calcineurin governs stress survival, sexual differentiation, and virulence of the human fungal
pathogen Cryptococcus neoformans. Calcineurin is activated by increased Ca2+ levels …

Cryptococcus neoformans is a human fungal pathogen and a major cause of fungal
meningitis in immunocompromised individuals. Treatment options for cryptococcosis are …

Low rates of homologous integration have hindered molecular genetic studies in
Cryptococcus neoformans over the past 20 years, and new tools that facilitate genome …

During infection, bacterial pathogens must adapt to a nutrient metal-limited environment that
is imposed by the host. The innate immune protein calprotectin inhibits bacterial growth in …

Cryptococcus neoformans and C. gattii are fungal pathogens that are most commonly found
in infections of the central nervous system, which cause life-threatening …

Urease is the most efficient enzyme known to date, and catalyzes the hydrolysis of urea
using two Ni (II) ions in the active site. Urease is a virulence factor in several human …

The opportunistic fungal pathogen Cryptococcus neoformans is a major cause of mortality in
immunocompromised individuals, resulting in more than 600,000 deaths per year. Many …