Hutchinson–Gilford progeria syndrome (HGPS) is an extremely rare premature aging
disease presenting many features resembling the normal aging process. HGPS patients die …

Ageing is a process that inevitably affects most living organisms and involves the
accumulation of macromolecular damage, genomic instability and loss of heterochromatin …

Background: Hutchinson-Gilford progeria syndrome is an extremely rare, fatal, segmental
premature aging syndrome caused by a mutation in LMNA yielding the farnesylated …

The alternatively spliced products of LMNA, lamin C and prelamin A (the precursor to lamin
A), are produced in similar amounts in most tissues and have largely redundant functions …

The incidence and prevalence of cardiovascular disease is highest among the elderly, in
part, due to deleterious effects of advancing age on the heart and blood vessels. Aging, a …

Hutchinson-Gilford progeria syndrome (HGPS) is a rare autosomal dominant genetic
disease that is caused by a silent mutation of the LMNA gene encoding lamins A and C …

Abstract Hutchinson-Gilford Progeria Syndrome (HGPS) is a devastating incurable
premature aging disease caused by accumulation of progerin, a toxic lamin A mutant …

In 1994 in the Journal of Cell Science, Hennekes and Nigg reported that changing valine to
arginine at the endoproteolytic cleavage site in chicken prelamin A abolishes its conversion …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder that causes
systemic accelerated aging in children. This syndrome is due to a mutation in the LMNA …

Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and
function. In this review, we focus on advances in our understanding of how the cytoplasmic …