Mitochondria are negatively affected by ageing leading to their inability to adapt to higher
levels of oxidative stress and this ultimately contributes to the systemic loss of muscle mass …

Skeletal muscle is a tissue with a low mitochondrial content under basal conditions, but it is
responsive to acute increases in contractile activity patterns (ie exercise) which initiate the …

Mitochondrial dysfunction affects cellular energy metabolism, but less is known about the
consequences for cytoplasmic biosynthetic reactions. We report that mtDNA replication …

The genetic integrity of iPSCs is an important consideration for therapeutic application. In
this study, we examine the accumulation of somatic mitochondrial genome (mtDNA) …

In forensics, age prediction is useful to narrow down the number of potential suspects
because it can provide some general characteristics for predicting appearance. Previous …

Ageing is a process that gradually increases the organism's vulnerability to death. It affects
different biological pathways, and the underlying cellular mechanisms are complex. In view …

The mechanisms underlying ageing have been discussed for decades, and advances in
molecular and cell biology of the last three decades have accelerated research in this area …

The mitochondrial theory of aging remains one of the most widely accepted aging theories
and implicates mitochondrial electron transport chain dysfunction with subsequent …

Some studies have pointed to the relationship between mitochondrial DNA (mtDNA)
mutations and age in different tissues, which are potentially interesting in aging research …

We review a recent paper in Genome Research by Guantes et al. showing that nuclear gene
expression is influenced by the bioenergetic status of the mitochondria. The amount of …