Tau and tauopathies
T Arendt, JT Stieler, M Holzer - Brain research bulletin, 2016 - Elsevier
Most neurodegenerative diseases are characterized by intracellular aggregates of insoluble
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
proteins. As for the majority of these disorders, aetiology and pathogenesis are only poorly …
The neuropathology and cerebrovascular mechanisms of dementia
L Raz, J Knoefel, K Bhaskar - Journal of Cerebral Blood Flow …, 2016 - journals.sagepub.com
The prevalence of dementia is increasing in our aging population at an alarming rate.
Because of the heterogeneity of clinical presentation and complexity of disease …
Because of the heterogeneity of clinical presentation and complexity of disease …
[PDF][PDF] PET imaging of tau deposition in the aging human brain
Tau pathology is a hallmark of Alzheimer's disease (AD) but also occurs in normal cognitive
aging. Using the tau PET agent 18 F-AV-1451, we examined retention patterns in cognitively …
aging. Using the tau PET agent 18 F-AV-1451, we examined retention patterns in cognitively …
Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer's disease
See Sarazin et al.(doi: 10.1093/brain/aww041) for a scientific commentary on this article.
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …
The advent of the positron emission tomography tracer 18 F-AV1451 provides the unique …
Tau positron emission tomographic imaging in aging and early A lzheimer disease
Objective Detection of focal brain tau deposition during life could greatly facilitate accurate
diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and …
diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and …
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology
The proliferation and activation of microglial cells is a hallmark of several neurodegenerative
conditions. This mechanism is regulated by the activation of the colony-stimulating factor 1 …
conditions. This mechanism is regulated by the activation of the colony-stimulating factor 1 …
[HTML][HTML] An autoradiographic evaluation of AV-1451 Tau PET in dementia
VJ Lowe, G Curran, P Fang, AM Liesinger… - Acta neuropathologica …, 2016 - Springer
Background It is essential to determine the specificity of AV-1451 PET for tau in brain
imaging by using pathological comparisons. We performed autoradiography in autopsy …
imaging by using pathological comparisons. We performed autoradiography in autopsy …
The locus coeruleus: essential for maintaining cognitive function and the aging brain
Research on cognitive aging has focused on how decline in various cortical and
hippocampal regions influence cognition. However, brainstem regions play essential …
hippocampal regions influence cognition. However, brainstem regions play essential …
Evaluation of tau imaging in staging Alzheimer disease and revealing interactions between β-amyloid and tauopathy
L Wang, TL Benzinger, Y Su, J Christensen… - JAMA …, 2016 - jamanetwork.com
Importance In vivo tau imaging may become a diagnostic marker for Alzheimer disease (AD)
and provides insights into the pathophysiology of AD. Objective To evaluate the usefulness …
and provides insights into the pathophysiology of AD. Objective To evaluate the usefulness …
[HTML][HTML] Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's …
Background Alzheimer's disease (AD) is the most common form of dementia, characterized
by progressive cognitive impairment and neurodegeneration. However, despite extensive …
by progressive cognitive impairment and neurodegeneration. However, despite extensive …