Medication‐related osteonecrosis of the jaw: new insights into molecular mechanisms and cellular therapeutic approaches

T Lombard, V Neirinckx, B Rogister… - Stem cells …, 2016 - Wiley Online Library
In recent years, medication‐related osteonecrosis of the jaw (MRONJ) became an arising
disease due to the important antiresorptive drug prescriptions to treat oncologic and …

Osteonecrosis of the jaw—a bone site-specific effect of bisphosphonates

JAF Vermeer, GAP Renders, V Everts - Current osteoporosis reports, 2016 - Springer
A known complication that can occur in patients using bisphosphonates (BPs) is
osteonecrosis of the jaw (ONJ). ONJ features bone exposure that may be associated with …

Osteonecrosis of the jaws (ONJ) in mice after extraction of teeth with periradicular disease

A Soundia, D Hadaya, N Esfandi, RS de Molon… - Bone, 2016 - Elsevier
Osteonecrosis of the jaws (ONJ) is a complication of antiresorptive medications, such as
denosumab or bisphosphonates, prescribed to patients with bone malignancy or …

[HTML][HTML] Multipotent mesenchymal stromal cell sheet therapy for bisphosphonate-related osteonecrosis of the jaw in a rat model

N Kaibuchi, T Iwata, M Yamato, T Okano, T Ando - Acta biomaterialia, 2016 - Elsevier
Bisphosphonates (BPs) inhibit bone resorption and are frequently used to treat
osteoporosis, bone metastasis, and other conditions that result in bone fragility. However …

[HTML][HTML] Immune modulation of CD4+CD25+ regulatory T cells by zoledronic acid

H Liu, SH Wang, SC Chen, CY Chen, JL Lo, TM Lin - BMC immunology, 2016 - Springer
Abstract Background CD4+ CD25+ regulatory T (Treg) cells suppress tumor immunity by
inhibiting immune cells. Manipulation of Treg cells represents a new strategy for cancer …

Therapeutic potential of mesenchymal stem cells for pulmonary complications associated with preterm birth

M Laube, A Stolzing, UH Thome, C Fabian - The international journal of …, 2016 - Elsevier
Preterm infants frequently suffer from pulmonary complications resulting in significant
morbidity and mortality. Physiological and structural lung immaturity impairs perinatal lung …

Hypoxic preconditioning enhances dental pulp stem cell therapy for infection-caused bone destruction

Y Wu, F Huang, X Zhou, S Yu, Q Tang, S Li… - … Engineering Part A, 2016 - liebertpub.com
The use of biological repair in infectious bone defects has been a major challenge for
clinicians. With potential for bone regeneration, stem cell therapy could be an effective …

[HTML][HTML] Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw

Y Matsuura, I Atsuta, Y Ayukawa, T Yamaza… - Stem cell research & …, 2016 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have been isolated from a variety of
tissues, including bone marrow, adipose, and mucosa. MSCs have the capacity for self …

双膦酸盐致颌骨坏死的大鼠模型研究

华洪飞, 王宁涛, 张文杰, 张伟杰, 张志愿, 王绍义 - 口腔颌面外科杂志, 2016 - cqvip.com
目的: 建立稳定的双膦酸盐相关颌骨坏死大鼠模型, 并初步探索其发病机制. 方法: 选取雌性SD
大鼠20 只, 8 周龄, 随机分为实验组(15 只), 腹腔注射唑来膦酸溶液; 对照组(5 只) …

Search for a reliable model for bisphosphonate-related osteonecrosis of the jaw: establishment of a model in pigs and description of its histomorphometric …

KT Mitsimponas, T Moest, C Iliopoulos, T Rueger… - British journal of oral …, 2016 - Elsevier
The pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) remains
unknown, and the development of a reliable experimental model would help to improve our …