The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a
unique structure, which can both stably bind to mRNAs and function as an anchor for diverse …

The Nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs
harboring premature termination codons (PTCs) but also regulates the abundance of a large …

Nonsense‐mediated mRNA decay (NMD) was originally coined to define a quality control
mechanism that targets mRNAs with truncated open reading frames due to the presence of a …

The nonsense-mediated mRNA decay (NMD) pathway functions to degrade both abnormal
and wild-type mRNAs. NMD is essential for viability in most organisms, but the molecular …

Nonsense-mediated messenger RNA (mRNA) decay (NMD) is a quality control mechanism
that degrades irregular or faulty mRNAs. NMD mainly degrades mRNAs, which contain a …

The exon junction complex (EJC) that is deposited onto spliced mRNAs upstream of exon–
exon junctions plays important roles in multiple post-splicing gene expression events, such …

In-frame premature termination codons (PTCs)(also referred to as nonsense mutations)
comprise~ 10% of all disease-associated gene lesions. PTCs reduce gene expression in …

Nonsense-mediated mRNA decay (NMD) has originally been described as a surveillance
mechanism to inhibit the expression of mRNAs with truncated open reading frames (ORFs) …

The presence of multiple variants for many mRNAs is a major contributor to protein diversity.
The processing of these variants is tightly controlled in a cell-type specific manner and has a …

The Exon Junction Complex (EJC) plays a central role in coupling post-transcriptional
processes in metazoans. This multi-protein complex is assembled onto messengers RNAs …