Understanding the mechanisms and drivers of antimicrobial resistance

AH Holmes, LSP Moore, A Sundsfjord, M Steinbakk… - The Lancet, 2016 - thelancet.com
To combat the threat to human health and biosecurity from antimicrobial resistance, an
understanding of its mechanisms and drivers is needed. Emergence of antimicrobial …

Clostridium difficile infection

WK Smits, D Lyras, DB Lacy, MH Wilcox… - Nature reviews Disease …, 2016 - nature.com
Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life
threatening, especially in elderly people and in patients who have dysbiosis of the gut …

[HTML][HTML] Culturing of 'unculturable'human microbiota reveals novel taxa and extensive sporulation

HP Browne, SC Forster, BO Anonye, N Kumar… - Nature, 2016 - nature.com
Our intestinal microbiota harbours a diverse bacterial community required for our health,
sustenance and wellbeing,. Intestinal colonization begins at birth and climaxes with the …

Within-host evolution of bacterial pathogens

X Didelot, AS Walker, TE Peto, DW Crook… - Nature Reviews …, 2016 - nature.com
Whole-genome sequencing has opened the way for investigating the dynamics and
genomic evolution of bacterial pathogens during the colonization and infection of humans …

Clostridium difficile infection: epidemiology, diagnosis and understanding transmission

JSH Martin, TM Monaghan, MH Wilcox - … reviews Gastroenterology & …, 2016 - nature.com
Clostridium difficile infection (CDI) continues to affect patients in hospitals and communities
worldwide. The spectrum of clinical disease ranges from mild diarrhoea to toxic megacolon …

Recent advances in the understanding of antibiotic resistance in Clostridium difficile infection

P Spigaglia - Therapeutic advances in infectious disease, 2016 - journals.sagepub.com
Clostridium difficile epidemiology has changed in recent years, with the emergence of highly
virulent types associated with severe infections, high rates of recurrences and mortality …

Photoexcited quantum dots for killing multidrug-resistant bacteria

CM Courtney, SM Goodman, JA McDaniel… - Nature materials, 2016 - nature.com
Multidrug-resistant bacterial infections are an ever-growing threat because of the shrinking
arsenal of efficacious antibiotics,,,. Metal nanoparticles can induce cell death, yet the toxicity …

Probiotics are effective at preventing Clostridium difficile-associated diarrhea: a systematic review and meta-analysis

CSM Lau, RS Chamberlain - International journal of general …, 2016 - Taylor & Francis
Introduction Clostridium difficile infection (CDI) is the leading cause of antibiotic-associated
diarrhea. CDI has increased in incidence and severity over the past decade, and is a …

Antimicrobial resistance, food safety, and one health: the need for convergence

SL Lammie, JM Hughes - Annual review of food science and …, 2016 - annualreviews.org
Antimicrobial resistance is a complex, multifaceted, urgent global health problem. There is
increasing concern about the emergence of multidrug-resistant superbugs. These …

Tools for the microbiome: nano and beyond

JS Biteen, PC Blainey, ZG Cardon, M Chun… - ACS …, 2016 - ACS Publications
The microbiome presents great opportunities for understanding and improving the world
around us and elucidating the interactions that compose it. The microbiome also poses …