Neurodevelopmental disorders (NDs) encompass a spectrum of neuropsychiatric
manifestations. Chromosomal regions 1q21. 1, 3q29, 15q11. 2, 15q13. 3, 16p11. 2, 16p13. 1 …

A growing body of research has examined the relationship between episodic memory
decline, the cognitive hallmark of Alzheimer's disease (AD), and the presence of …

Prefrontal dopamine levels are relatively increased in adolescence compared to adulthood.
Genetic variation of COMT (COMT Val158Met) results in lower enzymatic activity and higher …

Abstract Catechol-O-methyltransferase (COMT) modulates dopamine levels in the prefrontal
cortex. The human gene contains a polymorphism (Val 158 Met) that alters enzyme activity …

The catechol-O-methyltransferase (COMT) val158met single nucleotide polymorphism
(SNP) alters metabolic activity of the COMT enzyme regulating catecholamines, with the Val …

We have shown in a previous study that in the medial prefrontal cortex (mPFC) of Comt
knockout animals, uptake1 followed by oxidation accounts for approximately 50% and …

Post-traumatic stress disorder (PTSD) diagnosis entails exposure to an external stressful
event. Regarding such event as a reference point for disease onset represents a unique …

Catechol-O-methyltransferase (COMT) has two isoforms: soluble (S-COMT), which resides
in the cytoplasm, and membrane-bound (MB-COMT), anchored to intracellular membranes …

There is a long history of eye movement research in patients with psychiatric diseases for
which dysfunctions of neurotransmission are considered to be the major pathologic …

Exercise is a simple means that facilitates cognitive functions by activating molecular and
cellular signaling cascades involved in various central nervous system processes. However …