Microbiomes are ubiquitous and are found in the ocean, the soil, and in/on other living
organisms. Changes in the microbiome can impact the health of the environmental niche in …

Interactions with microbes affect many aspects of animal biology, including immune system
development, nutrition and health. In vertebrates, the gut microbiota is dominated by a small …

Whole metagenome analysis has the potential to reveal functional triggers of skin diseases,
but issues of cost, robustness and sampling efficacy have limited its application. Here, we …

Diagnoses that are both timely and accurate are critically important for patients with life-
threatening or drug resistant infections. Technological improvements in High-Throughput …

Microbial epidemiology and population genomics have previously been carried out near-
exclusively for organisms grown in vitro. Metagenomics helps to overcome this limitation, but …

The majority of plant viruses contain RNA genomes. Detection of viral RNA genomes in
infected plant material by next generation sequencing (NGS) is possible through the …

Rapidly assaying the diversity of a bacterial species present in a sample obtained from a
hospital patient or an environmental source has become possible after recent technological …

In this study we developed a genome-based method for detecting Staphylococcus aureus
subtypes from metagenome shotgun sequence data. We used a binomial mixture model and …

The rapid adoption of microbial whole genome sequencing in public health, clinical testing,
and forensic laboratories requires the use of validated measurement processes. Well …

The reliable detection of novel bacterial pathogens from next generation sequencing data is
a key challenge for microbial diagnostics. Current computational tools usually rely on …