MG53 is a member of the TRIM-family protein that acts as a key component of the cell
membrane repair machinery. MG53 is also an E3-ligase that ubiquinates insulin receptor …

Failure to repair the sarcolemma leads to muscle cell death, depletion of stem cells and
myopathy. Hence, membrane lesions are instantly sealed by a repair patch consisting of …

Ischemic injury to neurons represents the underlying cause of stroke to the brain. Our
previous studies identified MG53 as an essential component of the cell membrane repair …

Excessive retention of neutral lipids in cardiac lipid droplets (LDs) is a common observation
in cardiomyopathy. Thus, the systematic investigation of the cardiac LD proteome will help to …

Abstract Mitsugumin 53 (MG53) participates in the membrane repair of various cells, and
skeletal muscle is the major tissue that expresses MG53. Except for the regulatory effects of …

Background Hemodynamic load leads to cardiac hypertrophy and heart failure. While
afterload (pressure overload) induces concentric hypertrophy, elevation of preload (volume …

Alveolar epithelial and endothelial cell injury is a major feature of the acute respiratory
distress syndrome, in particular when in conjunction with ventilation therapies. Previously …

Mitsugumin 53 (MG53) is an E3 ligase that interacts with and ubiquitinates insulin receptor
substrate-1 (IRS-1) in skeletal muscle; thus, an MG53-IRS-1 interaction disruptor (MID) …

Disclosed herein are compositions and methods for repairing cell membranes. In addition,
the invention relates to therapeutic compositions comprising nucleotides and/or …

Disclosed herein are compositions and methods for measur ing the level of MG53 found in a
biological fluid as a biomarker for a disease or disorder, eg, tissue damage, exercise …