Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk
factors for the development of cardiovascular disease. They result from the interplay of …

The rising prevalences of type 2 diabetes and obesity constitute major threats to human
health globally. Powerful social and economic factors influence the distribution of these …

The genetic architecture of common traits, including the number, frequency, and effect sizes
of inherited variants that contribute to individual risk, has been long debated. Genome-wide …

Studies in mice and humans have revealed intriguing associations between host genetics
and the microbiome. Here we report a 16S rRNA-based analysis of the gut microbiome in …

The gut microbiota has been typically viewed as an environmental factor for human health.
Twins are well suited for investigating the concordance of their gut microbiomes and …

Systemic lupus erythematosus (SLE; OMIM 152700) is a genetically complex autoimmune
disease. Genome-wide association studies (GWASs) have identified more than 50 loci as …

Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …

Abstract Type 2 diabetes (T2DM) is a common complex metabolic disorder that has a strong
genetic predisposition. During the past decade, progress in genetic association studies has …

Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci
for type 2 diabetes (T2D), but most of its heritability still remains to be elucidated. In this …

As with other complex diseases, unbiased association studies followed by physiological and
experimental characterization have for years formed a paradigm for identifying genes or …