Transient receptor potential (TRP) channels are recently identified proteins that form a
versatile family of ion channels, the majority of which are calcium permeable and exhibit …

Cannabinoids have been used for many centuries to ease pain and in the past decade, the
endocannabinoid system has been implicated in a number of pathophysiological conditions …

Regulation of Ca2+ transport is vital in physiological processes, including lactation,
proliferation and apoptosis. The plasmalemmal Ca2+ pump isoform 2 (PMCA2) a calcium …

TRPM8 ion channels, the primary cold sensors in humans, are activated by innocuous
cooling (< 28° C) and cooling compounds (menthol, icilin) and are implicated in sensing …

The identification and validation of biomarkers for clinical applications remains an important
issue for improving diagnostics and therapy in many diseases, including prostate cancer …

A number of different ion channel types are involved in cell signaling networks, and
homeostatic regulatory mechanisms contribute to the control of ion channel expression …

Background Transient receptor potential cation channel, subfamily M, member 4 (TRPM4)
messenger RNA (mRNA) has been shown to be upregulated in prostate cancer (PCa) and …

Prostate cancer (PCa) is one of the most frequently diagnosed cancers in developed
countries. Several studies suggest that variations in calcium homeostasis are involved in …

Since its cloning a decade ago, TRPM8 channel has emerged as a promising prognostic
marker and a putative therapeutic target in prostate cancer (PCa). However, recent studies …

KIBRA is a regulator of the Hippo‐yes‐associated protein (YAP) pathway, which plays a
critical role in tumorigenesis. In the present study, we show that KIBRA is a positive regulator …