Oxidative stress and Huntington's disease: The good, the bad, and the ugly
Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …
signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a …
Is Huntington's disease a tauopathy?
Tauopathies are a subclass of neurodegenerative diseases typified by the deposition of
abnormal microtubule-associated tau protein within the cerebral tissue. Alzheimer's disease …
abnormal microtubule-associated tau protein within the cerebral tissue. Alzheimer's disease …
Transcriptome sequencing reveals aberrant alternative splicing in Huntington's disease
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by
a CAG expansion in the gene-encoding Huntingtin (HTT). Transcriptome dysregulation is a …
a CAG expansion in the gene-encoding Huntingtin (HTT). Transcriptome dysregulation is a …
Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels
L Rué, M Bañez-Coronel… - The Journal of …, 2016 - Am Soc Clin Investig
Huntington's disease (HD) is a polyglutamine disorder caused by a CAG expansion in the
Huntingtin (HTT) gene exon 1. This expansion encodes a mutant protein whose abnormal …
Huntingtin (HTT) gene exon 1. This expansion encodes a mutant protein whose abnormal …
Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease
GR Linares, CT Chiu, L Scheuing, Y Leng… - Experimental …, 2016 - Elsevier
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by CAG repeat
expansions in the huntingtin gene. Although, stem cell-based therapy has emerged as a …
expansions in the huntingtin gene. Although, stem cell-based therapy has emerged as a …
Activating transcription factor 6 derepression mediates neuroprotection in Huntington disease
Deregulated protein and Ca2+ homeostasis underlie synaptic dysfunction and
neurodegeneration in Huntington disease (HD); however, the factors that disrupt …
neurodegeneration in Huntington disease (HD); however, the factors that disrupt …
Characterization of behavioral, neuropathological, brain metabolic and key molecular changes in zQ175 knock-in mouse model of Huntington's disease
Huntington's disease (HD) is caused by an expansion of the trinucleotide poly (CAG) tract
located in exon 1 of the huntingtin (Htt) gene leading to progressive neurodegeneration in …
located in exon 1 of the huntingtin (Htt) gene leading to progressive neurodegeneration in …
Phosphodiesterase inhibition and regulation of dopaminergic frontal and striatal functioning: clinical implications
PRA Heckman, MA Van Duinen… - International Journal …, 2016 - academic.oup.com
Background: The fronto-striatal circuits are the common neurobiological basis for
neuropsychiatric disorders, including schizophrenia, Parkinson's disease, Huntington's …
neuropsychiatric disorders, including schizophrenia, Parkinson's disease, Huntington's …
Inhibition of DNA methyltransferases blocks mutant huntingtin-induced neurotoxicity
Y Pan, T Daito, Y Sasaki, YH Chung, X Xing… - Scientific reports, 2016 - nature.com
Although epigenetic abnormalities have been described in Huntington's disease (HD), the
causal epigenetic mechanisms driving neurodegeneration in HD cortex and striatum remain …
causal epigenetic mechanisms driving neurodegeneration in HD cortex and striatum remain …
[HTML][HTML] Huntington's disease as neurodevelopmental disorder: altered chromatin regulation, coding, and non-coding RNA transcription
E Kerschbamer, M Biagioli - Frontiers in neuroscience, 2016 - frontiersin.org
Huntington's disease (HD) is a monogenic autosomal dominant, fatal disorder due to CAG
trinucleotide expansion in exon 1 of the HD gene (HTT)(The Huntington's Disease …
trinucleotide expansion in exon 1 of the HD gene (HTT)(The Huntington's Disease …