Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Reversible acetylation was initially described as an epigenetic mechanism regulating DNA
accessibility. Since then, this process has emerged as a controller of histone and nonhistone …

Histone acetyltransferases (HATs) are epigenetic enzymes that install acetyl groups onto
lysine residues of cellular proteins such as histones, transcription factors, nuclear receptors …

The glucocorticoid receptor (GR) binds the human genome at> 10,000 sites but only
regulates the expression of hundreds of genes. To determine the functional effect of each …

Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many
disease states and have pivotal roles in various pathophysiological processes. However, the …

NuA4 catalyzes the acetylation of nucleosomes at histone H4, which is a well-established
epigenetic event, controlling many genomic processes in Saccharomyces cerevisiae. Here …

The reversible acetylation of lysines is one of the best characterized epigenetic
modifications. Its involvement in many key physiological and pathological processes has …

CREB binding protein (CBP) and p300 are critical regulators of hematopoiesis through both
their transcriptional coactivator and acetyltransferase activities. Loss or mutation of …

C646 inhibits the lysine acetyltransferases (KATs) p300 and CBP and represents the most
potent and selective small molecule KAT inhibitor identified to date. To gain insights into the …

Acetylation is a post-translational modification (PTM) that regulates chromatin dynamics and
function. Dysregulation of acetylation or acetyltransferase activity has been correlated with …