Megakaryopoiesis is a complex, stepwise process that takes place largely in the bone
marrow. At the apex of the hierarchy, hematopoietic stem cells undergo a number of lineage …

Essential thrombocythemia (ET) and primary myelofibrosis (PMF) are chronic diseases
characterized by clonal hematopoiesis and hyperproliferation of terminally differentiated …

Myeloproliferative neoplasms (MPNs) are clonal disorders characterized by increased
production of mature blood cells. Philadelphia chromosome-negative MPNs (Ph-MPNs) …

Somatic mutations in calreticulin (CALR) are present in approximately 40% of patients with
myeloproliferative neoplasms (MPN), but the mechanism by which mutant CALR is …

We conducted a genome-wide association study (GWAS) to identify novel predisposition
alleles associated with Philadelphia chromosome-negative myeloproliferative neoplasms …

Myeloproliferative neoplasm (MPN) patients frequently show co-occurrence of JAK2-V617F
and mutations in epigenetic regulator genes, including EZH2. In this study, we show that …

Molecular routine diagnostics for BCR‐ABL 1‐negative myeloproliferative neoplasms (MPN)
currently focusses on mutations in JAK 2, CALR and MPL. In recent years, recurrent …

Acute myeloid leukaemia (AML) is a molecularly and clinically heterogeneous disease.
Targeted sequencing efforts have identified several mutations with diagnostic and …

MPNs lacking those specific driver mutations are commonly called 'triple negatives', which
amount to 15% of ET and PMF and appear to share with phenotypic drivers the ability to …

Myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) are a group
of heterogeneous disorders of the hematopoietic system collectively known as Philadelphia …