The cellular and molecular landscapes of the developing human central nervous system
The human CNS follows a pattern of development typical of all mammals, but certain
neurodevelopmental features are highly derived. Building the human CNS requires the …
neurodevelopmental features are highly derived. Building the human CNS requires the …
Pluripotent stem cells in disease modelling and drug discovery
Experimental modelling of human disorders enables the definition of the cellular and
molecular mechanisms underlying diseases and the development of therapies for treating …
molecular mechanisms underlying diseases and the development of therapies for treating …
Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …
the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with …
Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
Developmental timing and critical windows for the treatment of psychiatric disorders
O Marín - Nature medicine, 2016 - nature.com
There is a growing understanding that pathological genetic variation and environmental
insults during sensitive periods in brain development have long-term consequences on …
insults during sensitive periods in brain development have long-term consequences on …
Identification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screen
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak
and its link to microcephaly and other neurological conditions, we performed a drug …
and its link to microcephaly and other neurological conditions, we performed a drug …
Altering the course of schizophrenia: progress and perspectives
MJ Millan, A Andrieux, G Bartzokis… - Nature reviews Drug …, 2016 - nature.com
Despite a lack of recent progress in the treatment of schizophrenia, our understanding of its
genetic and environmental causes has considerably improved, and their relationship to …
genetic and environmental causes has considerably improved, and their relationship to …
[HTML][HTML] Dishing out mini-brains: Current progress and future prospects in brain organoid research
I Kelava, MA Lancaster - Developmental biology, 2016 - Elsevier
The ability to model human brain development in vitro represents an important step in our
study of developmental processes and neurological disorders. Protocols that utilize human …
study of developmental processes and neurological disorders. Protocols that utilize human …
Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience
The scarcity of live human brain cells for experimental access has for a long time limited our
ability to study complex human neurological disorders and elucidate basic neuroscientific …
ability to study complex human neurological disorders and elucidate basic neuroscientific …
[HTML][HTML] Neural subtype specification from human pluripotent stem cells
Y Tao, SC Zhang - Cell stem cell, 2016 - cell.com
Human pluripotent stem cells (hPSCs) provide a model to study early neural development,
model pathological processes, and develop therapeutics. The generation of functionally …
model pathological processes, and develop therapeutics. The generation of functionally …