Metabolic adaptation is increasingly recognized as a key factor in tumor progression, yet its
involvement in metastatic bone disease is not understood. Bone is as an adipocyte-rich …

Adipocytes are a major component of the bone marrow that can critically affect metastatic
progression in bone. Understanding how the marrow fat cells influence growth, behavior …

Lung cancer is still the predominant cause of cancer-associated mortality worldwide. The
bone metastasis of lung cancer brings great suffering to the patient. Previous advances have …

Collagenolytic activity of cathepsin K is important for many physiological and pathological
processes including osteoclast-mediated bone degradation, macrophage function and …

A combination of virtual screening and biological testing was used to identify novel
cathepsin K (Cat K) inhibitors. A ligand-based pharmacophore model with five features was …

In this chapter, the contributions of cells in the immune system (monocyte-macrophages,
myeloid derived suppressor cells, mesenchymal stromal cells, T cell subsets, NK cells …

Background: The lysosomal cysteine protease cathepsin K is involved in bone remodeling
and is also expressed in the peritumoral stroma of carcinomas arising from different organs …