Suspected acute myocardial infarction (AMI) is one of the leading causes of admission to the
emergency departments in Western countries but also an increasing cause in many other …

Dilated cardiomyopathy is a rare cardiac disease characterized by left ventricular dilatation
and systolic dysfunction leading to heart failure and sudden cardiac death. Currently …

The heart either hypertrophies or dilates in response to familial mutations in genes encoding
sarcomeric proteins, which are responsible for contraction and pumping. These mutations …

Calcium binding and dissociation within the cardiac thin filament (CTF) is a fundamental
regulator of normal contraction and relaxation. Although the disruption of this complex …

Cardiac troponin (cTn) acts as a pivotal regulator of muscle contraction and relaxation and is
composed of three distinct subunits (cTnC: a highly conserved Ca 2+ binding subunit, cTnI …

Background: Familial hypertrophic cardiomyopathy (HCM) is an autosomal dominant
inherited disorder; mutations in at least 20 genes have been associated. Brugada syndrome …

The aim of this study is to make a foray in the world of constitutive elements of the
architectural and functional organizing of the cardiomyocytes involved in cardiomyopathies …

An “invariant proline” separates the myosin S1 head from its S2 tail and is proposed to be
critical for orienting S1 during its interaction with actin, a process that leads to muscle …

Ageing in humans is associated with a significant increase in the prevalence of
cardiovascular disease. We still do not fully understand the molecular mechanisms …

Background Back in the 1950s, the disease was first described by Teare who reported the
death of young adults with no prior symptoms. He stated the presence of hypertrophied heart …