Structure of the light‐driven sodium pump KR 2 and its implications for optogenetics

I Gushchin, V Shevchenko, V Polovinkin… - The FEBS …, 2016 - Wiley Online Library
A key and common process present in organisms from all domains of life is the maintenance
of the ion gradient between the inside and the outside of the cell. The gradient is generated …

The light‐driven sodium ion pump: A new player in rhodopsin research

HE Kato, K Inoue, H Kandori, O Nureki - BioEssays, 2016 - Wiley Online Library
Rhodopsins are one of the most studied photoreceptor protein families, and ion‐
translocating rhodopsins, both pumps and channels, have recently attracted broad attention …

[HTML][HTML] Crystal structure and functional characterization of a light-driven chloride pump having an NTQ motif

K Kim, SK Kwon, SH Jun, JS Cha, H Kim, W Lee… - Nature …, 2016 - nature.com
A novel light-driven chloride-pumping rhodopsin (ClR) containing an 'NTQ motif'in its
putative ion conduction pathway has been discovered and functionally characterized in a …

[HTML][HTML] Asymmetric functional conversion of eubacterial light-driven ion pumps

K Inoue, Y Nomura, H Kandori - Journal of Biological Chemistry, 2016 - ASBMB
In addition to the well-known light-driven outward proton pumps, novel ion-pumping
rhodopsins functioning as outward Na+ and inward Cl− pumps have been recently found in …

[HTML][HTML] The photochemistry of sodium ion pump rhodopsin observed by watermarked femto-to submillisecond stimulated Raman spectroscopy

Y Hontani, K Inoue, M Kloz, Y Kato, H Kandori… - Physical Chemistry …, 2016 - pubs.rsc.org
Krokinobacter rhodopsin 2 (KR2) is a recently discovered light-driven Na+ pump that holds
significant promise for application as a neural silencer in optogenetics. KR2 transports Na+ …

Mutant of a light-driven sodium ion pump can transport cesium ions

M Konno, Y Kato, HE Kato, K Inoue… - The Journal of …, 2016 - ACS Publications
Krokinobacter eikastus rhodopsin 2 (KR2) is a light-driven Na+ pump found in marine
bacterium. KR2 pumps Li+ and Na+, but it becomes an H+ pump in the presence of K+, Rb+ …

[HTML][HTML] Structural Mechanism for Light-driven Transport by a New Type of Chloride Ion Pump, Nonlabens marinus Rhodopsin-3*♦

T Hosaka, S Yoshizawa, Y Nakajima, N Ohsawa… - Journal of Biological …, 2016 - ASBMB
The light-driven inward chloride ion-pumping rhodopsin Nonlabens marinus rhodopsin-3
(NM-R3), from a marine flavobacterium, belongs to a phylogenetic lineage distinct from the …

[HTML][HTML] Real-time kinetics of electrogenic Na+ transport by rhodopsin from the marine flavobacterium Dokdonia sp. PRO95

AV Bogachev, YV Bertsova, ML Verkhovskaya… - Scientific Reports, 2016 - nature.com
Discovery of the light-driven sodium-motive pump Na+-rhodopsin (NaR) has initiated studies
of the molecular mechanism of this novel membrane-linked energy transducer. In this paper …

Role of Asn112 in a light-driven sodium ion-pumping rhodopsin

R Abe-Yoshizumi, K Inoue, HE Kato, O Nureki… - Biochemistry, 2016 - ACS Publications
Light-driven outward sodium-pumping rhodopsin (NaR) was recently found in marine
bacteria. Krokinobacter eikastus rhodopsin 2 (KR2) actively transports sodium and lithium …

[PDF][PDF] Structure of an inward proton-transporting Anabaena sensory rhodopsin mutant: mechanistic insights

B Dong, L Sánchez-Magraner, H Luecke - Biophysical journal, 2016 - cell.com
Microbial rhodopsins are light-activated, seven-α-helical, retinylidene transmembrane
proteins that have been identified in thousands of organisms across archaea, bacteria, fungi …