Autophagy in acute brain injury
Autophagy is an evolutionarily ancient mechanism that ensures the lysosomal degradation
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …
of old, supernumerary or ectopic cytoplasmic entities. Most eukaryotic cells, including …
Drug-repositioning opportunities for cancer therapy: novel molecular targets for known compounds
Highlights•De novo anticancer drug discovery is challenging and repurposing in oncology is
a promising field.•Drug repositioning increasingly emerges as faster, cheaper and …
a promising field.•Drug repositioning increasingly emerges as faster, cheaper and …
Calreticulin expression in human Non–Small cell lung cancers correlates with increased accumulation of antitumor immune cells and favorable prognosis
A high density of tumor-infiltrating mature dendritic cells (DC) and CD8+ T cells correlates
with a positive prognosis in a majority of human cancers. The recruitment of activated …
with a positive prognosis in a majority of human cancers. The recruitment of activated …
Immunological metagene signatures derived from immunogenic cancer cell death associate with improved survival of patients with lung, breast or ovarian …
AD Garg, D De Ruysscher, P Agostinis - Oncoimmunology, 2016 - Taylor & Francis
The emerging role of the cancer cell-immune cell interface in shaping tumorigenesis/
anticancer immunotherapy has increased the need to identify prognostic biomarkers …
anticancer immunotherapy has increased the need to identify prognostic biomarkers …
Anticancer metal drugs and immunogenic cell death
A Terenzi, C Pirker, BK Keppler, W Berger - Journal of inorganic …, 2016 - Elsevier
Conventional chemotherapeutics, but also innovative precision anticancer compounds, are
commonly perceived to target primarily the cancer cell compartment. However, recently it …
commonly perceived to target primarily the cancer cell compartment. However, recently it …
Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma
S Böhm, A Montfort, OMT Pearce, J Topping… - Clinical Cancer …, 2016 - AACR
Purpose: The purpose of this study was to assess the effect of neoadjuvant chemotherapy
(NACT) on immune activation in stage IIIC/IV tubo-ovarian high-grade serous carcinoma …
(NACT) on immune activation in stage IIIC/IV tubo-ovarian high-grade serous carcinoma …
[HTML][HTML] Mitochondrial regulation of cell death: a phylogenetically conserved control
Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and
anabolic pathways. Moreover, mitochondria play a key role in the signal transduction …
anabolic pathways. Moreover, mitochondria play a key role in the signal transduction …
Immunogenic apoptotic cell death and anticancer immunity
P Vandenabeele, K Vandecasteele, C Bachert… - Apoptosis in Cancer …, 2016 - Springer
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells
do not trigger an immune response but rather have anti-inflammatory properties. However …
do not trigger an immune response but rather have anti-inflammatory properties. However …
Development of potent small-molecule inhibitors to drug the undruggable steroid receptor coactivator-3
Protein–protein interactions (PPIs) play a central role in most biological processes, and
therefore represent an important class of targets for therapeutic development. However …
therefore represent an important class of targets for therapeutic development. However …
Non-canonical programmed cell death mechanisms triggered by natural compounds
M Diederich, C Cerella - Seminars in cancer biology, 2016 - Elsevier
Natural compounds are the fundament of pharmacological treatments and more than 50% of
all anticancer drugs are of natural origins or at least derived from scaffolds present in Nature …
all anticancer drugs are of natural origins or at least derived from scaffolds present in Nature …