The molecular hallmarks of epigenetic control
CD Allis, T Jenuwein - Nature Reviews Genetics, 2016 - nature.com
Over the past 20 years, breakthrough discoveries of chromatin-modifying enzymes and
associated mechanisms that alter chromatin in response to physiological or pathological …
associated mechanisms that alter chromatin in response to physiological or pathological …
Organization and function of the 3D genome
Understanding how chromatin is organized within the nucleus and how this 3D architecture
influences gene regulation, cell fate decisions and evolution are major questions in cell …
influences gene regulation, cell fate decisions and evolution are major questions in cell …
[HTML][HTML] A compendium of chromatin contact maps reveals spatially active regions in the human genome
The three-dimensional configuration of DNA is integral to all nuclear processes in
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …
eukaryotes, yet our knowledge of the chromosome architecture is still limited. Genome-wide …
Activation of proto-oncogenes by disruption of chromosome neighborhoods
Oncogenes are activated through well-known chromosomal alterations such as gene fusion,
translocation, and focal amplification. In light of recent evidence that the control of key genes …
translocation, and focal amplification. In light of recent evidence that the control of key genes …
[HTML][HTML] Chromatin domains: the unit of chromosome organization
How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …
unanswered today. Early biochemical and microscopic studies revealed the existence of …
[HTML][HTML] The 3D genome as moderator of chromosomal communication
Proper expression of genes requires communication with their regulatory elements that can
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …
[HTML][HTML] Insulated neighborhoods: structural and functional units of mammalian gene control
Understanding how transcriptional enhancers control over 20,000 protein-coding genes to
maintain cell-type-specific gene expression programs in all human cells is a fundamental …
maintain cell-type-specific gene expression programs in all human cells is a fundamental …
HiChIP: efficient and sensitive analysis of protein-directed genome architecture
Genome conformation is central to gene control but challenging to interrogate. Here we
present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield …
present HiChIP, a protein-centric chromatin conformation method. HiChIP improves the yield …
CTCF and cohesin in genome folding and transcriptional gene regulation
M Merkenschlager, EP Nora - Annual review of genomics and …, 2016 - annualreviews.org
Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
organization of chromosomes during the cell cycle. Genome folding in interphase provides …
HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen
Induction of broadly neutralizing antibodies (bnAbs) is a major HIV vaccine goal. Germline-
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …
targeting immunogens aim to initiate bnAb induction by activating bnAb germline precursor …