[HTML][HTML] Inflammatory bowel disease and cancer: The role of inflammation, immunosuppression, and cancer treatment

JE Axelrad, S Lichtiger, V Yajnik - World journal of …, 2016 - ncbi.nlm.nih.gov
In patients with inflammatory bowel disease (IBD), chronic inflammation is a major risk factor
for the development of gastrointestinal malignancies. The pathogenesis of colitis-associated …

Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy

W Ma, BM Gilligan, J Yuan, T Li - Journal of hematology & oncology, 2016 - Springer
Modulating immune inhibitory pathways has been a major recent breakthrough in cancer
treatment. Checkpoint blockade antibodies targeting cytotoxic T-lymphocyte antigen 4 …

The spectrum of serious infections among patients receiving immune checkpoint blockade for the treatment of melanoma

M Del Castillo, FA Romero, E Argüello… - Clinical Infectious …, 2016 - academic.oup.com
The risk of infection among patients receiving immune checkpoint blockade is unknown. We
retrospectively reviewed medical records of 740 patients with melanoma who received …

Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies

V Sibaud, N Meyer, L Lamant, E Vigarios… - Current opinion in …, 2016 - journals.lww.com
Dermatologic complications of anti-PD-1/PD-L1 immune checkpo... : Current Opinion in
Oncology Dermatologic complications of anti-PD-1/PD-L1 immune checkpoint antibodies …

Prevalence of autoimmune disease among patients with lung cancer: implications for immunotherapy treatment options

SA Khan, SL Pruitt, L Xuan, DE Gerber - JAMA oncology, 2016 - jamanetwork.com
Methods| This study was reviewed and approved by the institutional review board of the
University of Texas Southwestern Medical Center (STU 082012-040) and a waiver of …

[HTML][HTML] Acute renal allograft rejection after immune checkpoint inhibitor therapy for metastatic melanoma

L Spain, R Higgins, K Gopalakrishnan, S Turajlic… - Annals of …, 2016 - Elsevier
Immune checkpoint inhibitors such as ipilimumab and nivolumab improve survival in
patients with advanced melanoma and are increasingly available to clinicians for use in the …

Immune-related adverse events associated with immune checkpoint inhibitors

D Day, AR Hansen - BioDrugs, 2016 - Springer
Immune checkpoint inhibitors (ICIs), including antibodies targeting cytotoxic T-lymphocyte-
associated antigen 4 (CTLA-4) and programmed cell death protein-1 (PD-1), have shown …

Immune checkpoints and rheumatic diseases: what can cancer immunotherapy teach us?

M Van Der Vlist, J Kuball, TRD Radstake… - Nature Reviews …, 2016 - nature.com
The recent success of immune checkpoint blockade in cancer therapy illustrates the
importance of the inhibitory receptors cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) …

CTLA4 blockade elicits paraneoplastic neurological disease in a mouse model

LM Yshii, CM Gebauer, B Pignolet, E Maure… - Brain, 2016 - academic.oup.com
CTLA4 is an inhibitory regulator of immune responses. Therapeutic CTLA4 blockade
enhances T cell responses against cancer and provides striking clinical results against …

Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma

MI Carlo, MH Voss, RJ Motzer - Nature Reviews Urology, 2016 - nature.com
The management of advanced renal cell carcinoma (RCC) has dramatically changed over
the past decade. Therapies that target the vascular endothelial growth factor (VEGF) and …