Brain delivery is one of the major challenges in drug development because of the high
number of patients suffering from neural diseases and the low efficiency of the treatments …

Targeted delivery of therapeutic agents is an important way to improve the therapeutic index
and reduce side effects. To design nanoparticles for targeted delivery, both enhanced tumor …

Introduction: Delivery of macromolecular drugs is an important field in medical research.
However, macromolecules are usually unable to cross the cell membrane without the …

Abstract Pegylated liposomal doxorubicin (Lipo-Dox) is one of the few clinically used cancer
nanomedicines. Here we show that tumor-homing, redox-responsive and reversibly …

Conventional chemotherapy has little or no specificity for cancer cells, normally resulting in
low drug accumulation at the tumor region (inefficacy) and drug-induced severe side effects …

Background: Nanomedicine is an emerging therapeutic modality. Nanoparticles (NPs) are
potential vehicles for delivery of anticancer therapeutics. NPs can be designed to facilitate …

Surface modification/functionalization of nanoparticles (NPs) using polymeric protective
agents is an issue of great importance and actuality for drug delivery and targeting …

The pathological and physiological barriers of glioblastoma multiforme (GBM) lead to
insufficient extravasation and penetration of nano-sized therapeutics. As the main driver of …

Background: Tumor tissues possess many unique features, including leaky vasculature and
altered enzyme expression. An emerging field in anticancer drug delivery is to design …

In the development of therapeutic approaches for central nervous system diseases, a
significant obstacle is efficient drug delivery across the blood–brain barrier owing to its low …