[HTML][HTML] Recent advances in the synthesis of indolizines and their π-expanded analogues

B Sadowski, J Klajn, DT Gryko - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
Indolizine (pyrrolo [1, 2-a] pyridine) is one of the five isomers of indole and it serves as a
precursor for widespread indolizidine alkaloids. The straightforward synthesis of indolizines …

Synthesis of indolizines through aldehyde–amine–alkyne couplings using metal-organic framework Cu-MOF-74 as an efficient heterogeneous catalyst

GH Dang, HQ Lam, AT Nguyen, DT Le, T Truong… - Journal of …, 2016 - Elsevier
A crystalline copper-based metal-organic framework Cu-MOF-74 was synthesized, and was
characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM) …

Transition-metal-free synthesis of indolizines from electron-deficient alkenes via one-pot reaction using TEMPO as an oxidant

F Shi, Y Zhang, Z Lu, X Zhu, W Kan, X Wang, H Hu - Synthesis, 2016 - thieme-connect.com
A one-pot method for the synthesis of multisubstituted indolizines from α-halo carbonyl
compounds, pyridines, and electron-deficient alkenes is reported. The oxidative …

Direct alkenylation of alkylazaarenes with aldehydes through C (sp3)–H functionalization under catalytic InCl3 activation

Z Jamal, YC Teo, GS Lim - Tetrahedron, 2016 - Elsevier
Under the influence of InCl 3 as a Lewis acid catalyst, a methodology on the C (sp 3)–H
functionalization of alkylazaarenes has been demonstrated through the activation of …

Palladium-catalyzed external-oxidant-free coupling reactions between isoquinoline/quinoline N-oxides with olefins

T Guo, Y Liu, YH Zhao, PK Zhang, SL Han, HM Liu - Tetrahedron Letters, 2016 - Elsevier
A convenient and efficient approach for the synthesis of 1-alkenylisoquinolines and 2-
alkenylquinolines was developed via palladium-catalyzed coupling reactions between …

Palladium-catalyzed synthesis of 5-iminopyrrolones through isocyanide double insertion reaction with terminal alkynes and water

Y He, YC Wang, K Hu, XL Xu, HS Wang… - The Journal of Organic …, 2016 - ACS Publications
With the combination of Pd (dppf) Cl2 and Cu (OAc) 2, a variety of 5-iminopyrrolones were
synthesized in moderate to good yields from terminal alkynes, isocyanide, and water via …

Transition Metal‐Free Synthesis of 3‐Alkynylpyrrole‐2‐carboxylates via Michael Addition/Intramolecular Cyclodehydration

Q Teng, Y Xu, Y Liang, H Wang… - Advanced Synthesis & …, 2016 - Wiley Online Library
A transition metal‐free and efficient method for the synthesis of 3‐alkynylpyrrole‐2‐
carboxylates from diynones and glycine esters or 2‐aminoacetophenone hydrochloride has …

Synthesis of Furans and Pyrroles from 2‐Alkoxy‐2, 3‐dihydrofurans Through a Nucleophilic Substitution‐Triggered Heteroaromatization

C Liu, L Zhou, W Huang, M Wang… - Advanced Synthesis & …, 2016 - Wiley Online Library
An effective method to synthesize α‐functionalized furan and pyrrole derivatives was
developed using 2‐alkoxy‐2, 3‐dihydrofurans as modular precursors. This protocol featured …

Facile synthesis of 2-alkenylazaarenes via dehydrative coupling of 2-methylazaarenes with aldehydes 'on water'

S Fu, L Wang, H Dong, J Yu, L Xu, J Xiao - Tetrahedron Letters, 2016 - Elsevier
A catalyst-free dehydrative coupling of 2-methylazaarenes with aldehydes 'on water'has
been developed for efficient synthesis of (E)-2-alkenylazaarenes. The challenging …

Transition‐Metal‐Free Synthesis of Nitrogen Containing Heterocycles With Fully Substituted N‐fused Pyrrole Rings

D Bakshi, A Singh - Asian Journal of Organic Chemistry, 2016 - Wiley Online Library
The efficient synthesis of C‐2 alkylated indolizine, pyrrolo [1, 2‐a] isoquinoline, and pyrrolo
[1, 2‐a] quinoline derivatives utilizing a single reactivity platform is described. Employing a …