Resveratrol and curcumin are natural products with important therapeutic properties useful
to treat several human diseases, including cancer. In the last years, the number of studies …

Metastatic associated proteins (MTA) are integrators of upstream regulatory signals with the
ability to act as master coregulators for modifying gene transcriptional activity. The MTA …

Aberrant DNA methylation is a frequent epigenetic alteration in cancer cells that has
emerged as a pivotal mechanism for tumorigenesis. Accordingly, novel therapies targeting …

Overexpression of the epigenetic modifier metastasis-associated protein 1 (MTA1) is
associated with aggressive human prostate cancer. The purpose of this study was to …

Background Signal transducers and activators of transcription (STAT) proteins are critical
transcription factor that are aberrantly activated in various types of malignancies, including …

This study investigated the effects of resveratrol (RSV) on retinal functions, glutamate
transporters (GLAST) and glutamine synthetase (GS) expression in diabetic rats retina, and …

The rise in cancer incidence and mortality in developing countries together with the human
and financial cost of current cancer therapy mandates a closer look at alternative ways to …

Post-translational modifications can affect gene expression in a long-term manner without
changes in the primary nucleotide sequence of the DNA. These epigenetic alterations …

In the last decade, strong evidence has emerged on the link between diet and epigenetic
mechanisms of diseases. Dietary bioactive molecules from vegetables, fruits, and some …

Background/Aim: The serine/threonine-protein kinase B-Raf (BRAF) V600E mutant
(BRAFV600E) inhibitor vemurafenib, has improved clinical outcomes for patients with …