Collagen and matrix deposition by fibroblasts is an essential part of wound healing but also
contributes to pathologic remodeling of organs leading to substantial morbidity and mortality …

Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease of unknown etiology. The
development of pulmonary hypertension (PH) is considered the single most significant …

Pulmonary hypertension (PH) complicating chronic parenchymal lung disease, such as
idiopathic pulmonary fibrosis, results in significant morbidity and mortality. Since the hypoxia …

The molecular mechanisms of chronic pain are poorly understood and effective mechanism-
based treatments are lacking. Here, we report that mice lacking adenosine deaminase …

Radiation-induced pulmonary fibrosis is a severe side effect of thoracic irradiation, but its
pathogenesis remains poorly understood and no effective treatment is available. In this …

Group III pulmonary hypertension (PH) is a highly prevalent and deadly lung disorder with
limited treatment options other than transplantation. Group III PH affects patients with …

Idiopathic pulmonary fibrosis is a devastating lung disease with limited treatment options.
The signaling molecule adenosine is produced in response to injury and serves a protective …

Background and Purpose Adenosine A2A receptor stimulation promotes the synthesis of
collagen type I and type III (Col1 and Col3), mediators of fibrosis and scarring. The A2A …

Increased sympathetic nervous system (SNS) activity is associated with cardiovascular
diseases but its role has not been completely explored in pulmonary hypertension (PH) …

Heart failure remains a leading cause of morbidity and mortality in the United States. Many
of the deaths attributed to heart failure are sudden, presumably due to lethal arrhythmia. It is …