A targeted delivery system based on the polymeric nanoparticles as a drug carrier
represents a marvelous avenue for cancer therapy. The pivotal characteristics of this system …

By deconvoluting 238,073 bioactive molecules in the ChEMBL library into extended Murcko
ring systems, we identified a set of 2245 ring systems present in at least 10 molecules …

Genetic mutations of oncogenes often underlie deranged cell growth and altered
differentiation pathways leading to malignant transformation of B-lymphocytes. However …

In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of
protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 …

Despite major advances in first-line treatment, a significant proportion of patients with diffuse
large B-cell lymphoma (DLBCL) will experience treatment failure. Prognosis is particularly …

Chronic myeloid leukaemia (CML) is a myeloproliferative disorder promoted by the
constitutive tyrosine kinase activity of Bcr-Abl oncoprotein. Although treatment with the Bcr …

Using affinity purification MS approaches, we have identified a novel role for casein kinase II
(CKII) in the modification of the polymerase associated factor complex (PAF-C). Our data …

Abstract Interleukin-7 and interleukin-7 receptor are essential for normal T-cell development
and homeostasis, whereas excessive interleukin-7/interleukin-7 receptor-mediated …

Abstract Design of novel coumarin derivatives as CK2 inhibitors were attempted by targeting
the interaction with the hinge region. A set of substituents capable of forming a hydrogen …

Interleukin-7 and IL7R are essential for normal T-cell development and homeostasis,
whereas excessive interleukin-7/IL7R-mediated signaling promotes leukemogenesis …