Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are a continuum of
lung changes arising from a wide variety of lung injuries, frequently resulting in significant …

Toll-like receptors (TLRs) are components of the innate immune system that respond to
exogenous infectious ligands (pathogen-associated molecular patterns, PAMPs) and …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

The pulmonary endothelium is a dynamic, metabolically active layer of squamous
endothelial cells ideally placed to mediate key processes involved in lung homoeostasis …

Cold-inducible RNA-binding protein (CIRP) is a damage-associated molecular pattern
(DAMP) molecule which stimulates proinflammatory cytokine release in hemorrhage and …

Microvascular leakage due to endothelial barrier dysfunction is a prominent feature of T
helper 2 (Th2) cytokine mediated allergic inflammation. Interleukin-4 (IL-4) is a potent Th2 …

Background and Objectives Damage‐associated molecular patterns (DAMP s) are found in
transfusion products, but their potential impacts are not fully understood. We examined the …

Inflammatory and ischemic cardiovascular diseases, especially atherosclerosis and
myocardial infarction, remain the number one cause of death in the Western world, whereas …

The pathogenesis of sepsis is complex. Mitochondrial dysfunction, which is responsible for
energy metabolism, intrinsic apoptotic pathway, oxidative stress, and systemic inflammatory …

Introduction: Myocardial infarction (MI) provokes an intense inflammatory response that can
lead to left ventricular adverse remodeling and heart failure (HF). The prognosis of HF …