Acetaminophen (APAP) hepatotoxicity is characterized by an extensive oxidative stress.
However, its source, pathophysiological role and possible therapeutic potential if targeted …

The current test systems employed by pharmaceutical industry are poorly predictive for drug-
induced liver injury (DILI). The 'MIP-DILI'project addresses this situation by the development …

Background & Aims Acetaminophen (APAP)-induced liver injury is the most frequent cause
of acute liver failure in the US and many other countries. Metabolism of APAP results in …

Acetaminophen (APAP) overdose causes hepatotoxicity involving mitochondrial dysfunction
and c-jun N-terminal kinase (JNK) activation. Because the safe limit of APAP dosing is …

Overdose of acetaminophen (APAP) causes severe liver injury and even acute liver failure
in both mice and human. A recent study by Kim et al.(, Metformin ameliorates …

Drug-induced cholestasis (DIC) is recognized as one of the prime mechanisms for DILI.
Hence, earlier detection of drug candidates with cholestatic signature is crucial. Recently …

Background Drug safety is one of the hottest topics in daily medical practice, particularly with
regard to approving new medication or questioning the possibility of withdrawing a drug …

We aimed to evaluate the possible protective effect of a UTR antagonist and to determine
the effect of the antagonist on ALT and AST levels in serum, the mRNA expression level of …

Acetaminophen is a commonly used analgesic that can cause severe hepatotoxicity in
overdose. Despite old age and frailty being associated with extensive and long-term …

Rhizoma Dioscorea bulbifera, the tuber of Dioscorea bulbifera L., has been used to treat
various diseases. However, the clinical application has been limited for its hepatotoxicity. In …