Cellular stress or apoptosis triggers the release of ATP, ADP and other nucleotides into the
extracellular space. Extracellular nucleotides function as autocrine and paracrine signalling …

The oral cavity is inhibited by many of the bacterial species. Some of them have a key role in
the development of oral disease. Interrelationships between oral microbiome and systemic …

Highlights•Adenosine protects tissues against excessive inflammation and promotes tissue
repair.•The adenosine pathway is hijacked to dampen anti-tumor immunity.•Targeting CD73 …

Canonical inflammasome activation induces a caspase-1/gasdermin D (Gsdmd)–dependent
lytic cell death called pyroptosis that promotes antimicrobial host defense but may contribute …

Abstract Background Ovarian cancer (OvCA) tissues show abundant expression of the
ectonucleotidases CD39 and CD73 which generate immunomodulatory adenosine, thereby …

Conventional chemotherapeutics, but also innovative precision anticancer compounds, are
commonly perceived to target primarily the cancer cell compartment. However, recently it …

Despite the significant increase in our knowledge on cancer initiation and progression, and
the development of novel cancer treatments, overall patient survival rates have thus far only …

Photodynamic therapy (PDT), a regulatory approved cancer treatment, is reported to be
capable of causing immunogenic apoptosis. The current data reveal PDT can cause the …

Oncolytic viruses (OVs) comprise an emerging cancer therapeutic modality whose activity
involves both direct tumor cell lysis and the induction of immunogenic cell death (ICD) …

Oncolytic viruses (OVs) demonstrate the ability to replicate selectively in cancer cells,
resulting in antitumor effects by a variety of mechanisms, including direct cell lysis and …