Alzheimer's disease (AD) is one of the most common neurodegenerative disorders, which
causes the deterioration of memory and other cognitive abilities of the elderly. Previous lines …

Background: Alzheimer disease (AD) is a neurodegenerative disorder occurring in elderly
people and leading to the loss of memory, practical and speaking habits. In spite of …

Cholinergic impairments and tau accumulation are hallmark pathologies in sporadic
Alzheimer's disease (AD), however, the intrinsic link between tau accumulation and …

The α7 and α4β2 neuronal nicotinic receptors belonging to the family of ligand-gated ion
channels are most prevalent in the brain, and are implicated in various neurodegenerative …

The histopathological hallmarks present in Alzheimer's disease (AD) brain are plaques of Aβ
peptide, neurofibrillary tangles of hyperphosphorylated tau protein, and a reduction in …

Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Neuropathological
hallmarks of AD are amyloid plaques composed of amyloid-β (Aβ), neurofibrillary tangles …

Materials and Methods Participants All participants signed an informed consent. The
research was approved by the Ethics Committee of the University Hospital Kralovske …

Nicotinic acetylcholine receptors (nAChRs) have been pursued for decades as potential
molecular targets to treat cognitive dysfunction in Alzheimer's disease (AD) due to their …

Aging is characterized by an increase in inter-individual variability in cognitive capacity.
Slight decrements in learning and memory emerge; however, age-related shifts in …

A Doença de Alzheimer (DA) é a mais comum desordem neurodegenerativa e a principal
causa de demência re lacionada a idade. Os números em crescimento de pessoas afetadas …